NM:补充低聚果糖或可改善血糖稳态(综述)

Nutrition and Metabolism

1/25/18Review

2.974

影响因子

原标题:低聚果糖和葡萄糖内稳态:动物模型的系统回顾和荟萃分析

① 系统回顾截止于2016年的29项试验,对其中12项进行荟萃分析;② 动物模型无论健康、肥胖或糖尿病和低脂或高脂饮食,摄入低聚果糖(FOS)可降低空腹血糖水平,且与剂量成线性关系;③ 空腹胰岛素水平也随FOS的补充呈线性下降,但该效应只对低脂饮食的啮齿动物有显著性;④ 机制为:摄入FOS产生较高短链脂肪酸,调节肠道菌群,改变胆汁酸组成利于GLP-1分泌,减少促炎物质产生;⑤ 不论健康状况和饮食情况,补充FOS对动物葡萄糖内稳态有显著影响。

低聚果糖 益生元 膳食纤维 血糖 血胰岛素

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Title:
Fructo-oligosaccharides and glucose homeostasis: a systematic review and meta-analysis in animal models

DOI:
10.1186/s12986-018-0245-3

Abstract & Authors展开

Abstract:
The aim of this systematic review was to assess the effect of fructo-oligosaccharide supplementation on glucose homeostasis. The search process was based on the selection of publications listed in the Pubmed-Medline database until April 2016 to identify studies evaluating the impact of short-chain fructo-oligosaccharides or oligofructose on glucose homeostasis. Twenty-nine trials were included in the systematic review and the meta-analysis was performed on twelve of these papers according to the inclusion criteria. Fasting blood concentrations of glucose and insulin were selected as pertinent criteria of glucose homeostasis for the meta-analysis. The consumption of fructo-oligosaccharides decreased fasting blood glycaemia levels, whatever the metabolic status (healthy, obese or diabetic) and diet (low-fat or high-fat) throughout the experiment. This reduction was linear with prebiotic dose (from 0 to 13% of the feed). Fasting insulinaemia also decreased linearly with fructo-oligosaccharide supplementation but the reduction was only significant in rodents fed a low-fat diet. Potential underlying mechanisms include gut bacterial fermentation of fructo-oligosaccharides to short-chain fatty acids (SCFA) and bacterial modulation of bile acids, both interacting with host metabolism.This systemic review, followed by the meta-analysis, provides evidence that fructo-oligosaccharide supplementation has a significant effect on glucose homeostasis whatever the health status and diet consumed by animals.

All Authors:
Cindy Le Bourgot, Emmanuelle Apper, Sophie Blat , Frédérique Respondek

First Authors:
Cindy Le Bourgot

Correspondence:
Frédérique Respondek

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