BMCB:人体微生物组的进化(综述)

BMC Biology

2017-12-27Review

6.779

影响因子

原标题:进化中的人类微生物组

① 不同种群的人类体内微生物组差异显著,但在高级灵长类动物的比较中,人类自身的差异就很小了;② 将视角放大到脊椎动物谱系,可知物种进化对微生物组影响显著,进化上越相近的物种微生物组越相似;③ 宿主体内的微生物组进化的可能机制:宿主为肠道菌群设定多种过滤器,使菌群更加多样化;④ 某种微生物进化后获得某个功能,与宿主某个基因的功能相似;⑤ 当宿主的基因组发生突变,该基因功能丢失后,含有进化后的物种的微生物组适应性更高。

进化

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Title:
The human microbiome in evolution

DOI:
10.1186/s12915-017-0454-7

Abstract & Authors展开

Abstract:
The trillions of microbes living in the gut-the gut microbiota-play an important role in human biology and disease. While much has been done to explore its diversity, a full understanding of our microbiomes demands an evolutionary perspective. In this review, we compare microbiomes from human populations, placing them in the context of microbes from humanity's near and distant animal relatives. We discuss potential mechanisms to generate host-specific microbiome configurations and the consequences of disrupting those configurations. Finally, we propose that this broader phylogenetic perspective is useful for understanding the mechanisms underlying human-microbiome interactions.

All Authors:
Emily R Davenport,Jon G Sanders,Se Jin Song,Katherine R Amato,Andrew G Clark,Rob Knight

First Authors:
Emily R Davenport,Jon G Sanders

Correspondence:
Rob Knight

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