南京农业大学:金针菇多糖可改善模型小鼠的学习记忆损伤

Food and Function

1/25/18Article

3.247

影响因子

原标题:金针菇多糖通过调节肠道菌群组成改善莨菪碱诱导的小鼠学习和记忆损伤

① 金针菇多糖(FVP)可显著增加莨菪碱诱导的模型小鼠肠道梭菌和芽孢杆菌纲相对丰度,显著降低拟杆菌、丹毒丝菌和放线菌纲相对丰度;② 将FVP组小鼠粪便菌群移植至模型小鼠,可改善其学习和记忆能力;③ FVP和FVP产生的粪便菌群均可显著增加模型小鼠跨平台次数和游泳距离,显著减少逃避潜伏期和游泳总距离;④ 并调节细胞因子IL-1β、TNF-α、IL-6和IL-10;⑤ FVP调节肠道菌群,改善莨菪碱诱导的小鼠学习和记忆损伤,其机制可能是抑制神经炎症。

金针菇多糖 肠道菌群 粪菌移植 学习记忆

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Title:
Flammulina velutipes polysaccharides improve scopolamine-induced learning and memory impairment of mice by modulating gut microbiota composition

DOI:
10.1039/C7FO01991B

Abstract & Authors展开

Abstract:
Flammulina velutipes polysaccharides (FVP) have been proved to be effective on improving impairment of learning and memory of mice. But an underlying mechanism remains unclear. The aim of this study was to investigate the relationship between memory improvement and gut microbiota regulation of FVP. Results showed a significantly decrease of the relative abundances in Clostridia and Bacilli, but significantly increase in Bacteroidia, Erysipelotrichia and Actinobacteria in the FVP-treated group versus the control group. Fecal microbiota transplantation of mice with ‘FVP microbiota’ derived from FVP-fed mice showed improved learning and memory function compared with colonization with ‘common microbiota’ derived from control individuals. FVP and ‘FVP microbiota’ significantly increased the numbers of platform crossing and swimming distance of mice in the probe test and decreased the escape latency and total swimming distance of mice in the hidden platform test. Moreover, FVP and ‘FVP microbiota’ regulated the cytokines such as IL-1β, TNF-α, IL-6 and IL-10, suggesting that the mechanism maybe through suppressing neuroinflammation. This study indicated that regulation of the gut microbiome may have a causal role in improving scopolamine-induced impairment of learning and memory.

All Authors:
Anxiang Su , Wenjian Yang , Liyan Zhao , Fei Pei , Biao Yuan , Lei Zhong , Gaoxing Ma , Qiuhui Hu

First Authors:
Anxiang Su

Correspondence:
Qiuhui Hu

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