BMJ Open:孕期摄入益生菌是否有助于降低子痫前期和早产风险?

BMJ Open





① 研究纳入1999至2008年70149例挪威母亲及儿童队列研究(无慢性疾病、胎盘前置/环扎术/严重畸形胎儿、头胎)的问卷调查数据;② 孕晚期补充益生菌牛奶与较低的子痫前期风险有显著相关性;③ 孕早期补充益生菌可显著降低自发性早产的风险;④ 孕期摄入益生菌或可降低子痫前期和早产的风险,原因也许是益生菌可提高孕妇免疫力,预防炎症的发生,且该作用与摄入的时间有关;⑤ 未来需开展随机对照试验以研究益生菌与子痫前期和早产风险的因果关系。

子痫前期 早产 孕期 益生菌


Timing of probiotic milk consumption during pregnancy and effects on the incidence of preeclampsia and preterm delivery: a prospective observational cohort study in Norway


Abstract & Authors展开

To investigate whether the timing of probiotic milk intake before, during early or late pregnancy influences associations with preeclampsia and preterm delivery. Population based prospective cohort study. Norway, between 1999 and 2008. 70 149 singleton pregnancies resulting in live-born babies from the Norwegian Mother and Child Cohort Study (no chronic disease, answered questionnaires, no placenta previa/cerclage/serious malformation of fetus, first enrolment pregnancy). Only nulliparous women (n=37 050) were included in the preeclampsia analysis. Both iatrogenic and spontaneous preterm delivery (between gestational weeks 22+0 and 36+6) with spontaneous term controls (between gestational weeks 39+0 and 40+6) were included in the preterm delivery analysis resulting in 34 458 cases. Adjusted OR for preeclampsia and preterm delivery according to consumption of probiotic milk at three different time periods (before pregnancy, during early and late pregnancy). Probiotic milk intake in late pregnancy (but not before or in early pregnancy) was significantly associated with lower preeclampsia risk (adjusted OR: 0.80 (95% CI 0.68 to 0.94) p-value: 0.007). Probiotic intake during early (but not before or during late pregnancy) was significantly associated with lower risk of preterm delivery (adjusted OR: 0.79 (0.64 to 0.97) p-value: 0.03). In this observational study, we found an association between timing of probiotic milk consumption during pregnancy and the incidence of the adverse pregnancy outcomes preeclampsia and preterm delivery. If future randomised controlled trials could establish a causal association between probiotics consumption and reduced risk of preeclampsia and preterm delivery, recommending probiotics would be a promising public health measure to reduce these adverse pregnancy outcomes.

All Authors:
Mahsa Nordqvist,Bo Jacobsson,Anne-Lise Brantsæter,Ronny Myhre,Staffan Nilsson,Verena Sengpiel

First Authors:
Mahsa Nordqvist

Mahsa Nordqvist