一图读懂:促进IBD的所有已知环境因素(必读)

Nature Reviews Gastroenterology & Hepatology

2017-10-11Review

13.678

影响因子

原标题:炎症性肠病中的环境触发因素:对研究进展和证据的综述

① 肠道微生态失衡与炎症性肠病(IBD)的发生发展密切相关,但失衡是原发还是继发事件尚不明确;② 分娩方式、母乳/奶粉喂养、抗生素使用及感染等生命早期因素,改变粘膜防御并触发免疫响应的环境污染,高海拔相关缺氧症,都可能促进IBD;③ 可能的环境因素众多,它们参与IBD发生的机制异常复杂,系统生物学提供了揭示IBD中分子改变的可能性;④ IBD发生机制的复杂性,也提示我们治疗IBD或许需要综合性系统性的方法,而非目前所用的单一方法。 #一张图读懂系列文献#

炎症性肠病 环境因素 微生态失衡

图片

Title:
Environmental triggers in IBD: a review of progress and evidence

DOI:
10.1038/nrgastro.2017.136

Abstract & Authors展开

Abstract:
A number of environmental factors have been associated with the development of IBD. Alteration of the gut microbiota, or dysbiosis, is closely linked to initiation or progression of IBD, but whether dysbiosis is a primary or secondary event is unclear. Nevertheless, early-life events such as birth, breastfeeding and exposure to antibiotics, as well as later childhood events, are considered potential risk factors for IBD. Air pollution, a consequence of the progressive contamination of the environment by countless compounds, is another factor associated with IBD, as particulate matter or other components can alter the host's mucosal defences and trigger immune responses. Hypoxia associated with high altitude is also a factor under investigation as a potential new trigger of IBD flares. A key issue is how to translate environmental factors into mechanisms of IBD, and systems biology is increasingly recognized as a strategic tool to unravel the molecular alterations leading to IBD. Environmental factors add a substantial level of complexity to the understanding of IBD pathogenesis but also promote the fundamental notion that complex diseases such as IBD require complex therapies that go well beyond the current single-agent treatment approach. This Review describes the current conceptualization, evidence, progress and direction surrounding the association of environmental factors with IBD.

All Authors:
Ashwin N Ananthakrishnan, Charles N Bernstein, Dimitrios Iliopoulos, Andrew Macpherson, Markus F Neurath, Raja A Raja Ali, Stephan R Vavricka,Claudio Fiocchi

First Authors:
Ashwin N Ananthakrishnan

Correspondence:
Ashwin N Ananthakrishnan

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