肠道菌群多样性越低,动脉硬化越厉害

European Heart Journal

5/9/18Article

19.651

影响因子

原标题:肠道微生物多样性与女性动脉僵硬度降低有关

① 在617名中年女性中发现脉搏波速度(PWV,体现动脉僵硬程度)与肠道菌群α-多样性负相关,7个OTU与PWV显著负相关;② 肠道菌群因素可解释约8.3%的PWV变化,远大于内脏脂肪和胰岛素抵抗;③ 吲哚丙酸、氧化三甲胺和苯乙酰谷氨酰胺等菌群代谢物,以及胰岛素抵抗、内脏脂肪、C-反应蛋白等代谢综合征和炎症指标,不是介导菌群对PWV影响的主要因素;④ 肠道菌群多样性与女性动脉僵硬度负相关,独立于代谢综合征,以菌群为靶点或可改善动脉老化。

心血管 动脉僵硬度 动脉硬化 动脉老化 肠道菌群多样性

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Title:
Gut microbial diversity is associated with lower arterial stiffness in women

DOI:
10.1093/eurheartj/ehy226

Abstract & Authors展开

Abstract:
The gut microbiome influences metabolic syndrome (MetS) and inflammation and is therapeutically modifiable. Arterial stiffness is poorly correlated with most traditional risk factors. Our aim was to examine whether gut microbial composition is associated with arterial stiffness. We assessed the correlation between carotid-femoral pulse wave velocity (PWV), a measure of arterial stiffness, and gut microbiome composition in 617 middle-aged women from the TwinsUK cohort with concurrent serum metabolomics data. Pulse wave velocity was negatively correlated with gut microbiome alpha diversity (Shannon index, Beta(SE)= -0.25(0.07), P = 1 × 10-4) after adjustment for covariates. We identified seven operational taxonomic units associated with PWV after adjusting for covariates and multiple testing-two belonging to the Ruminococcaceae family. Associations between microbe abundances, microbe diversity, and PWV remained significant after adjustment for levels of gut-derived metabolites (indolepropionate, trimethylamine oxide, and phenylacetylglutamine). We linearly combined the PWV-associated gut microbiome-derived variables and found that microbiome factors explained 8.3% (95% confidence interval 4.3-12.4%) of the variance in PWV. A formal mediation analysis revealed that only a small proportion (5.51%) of the total effect of the gut microbiome on PWV was mediated by insulin resistance and visceral fat, c-reactive protein, and cardiovascular risk factors after adjusting for age, body mass index, and mean arterial pressure. Gut microbiome diversity is inversely associated with arterial stiffness in women. The effect of gut microbiome composition on PWV is only minimally mediated by MetS. This first human observation linking the gut microbiome to arterial stiffness suggests that targeting the microbiome may be a way to treat arterial ageing.

All Authors:
Cristina Menni,Chihung Lin,Marina Cecelja,Massimo Mangino,Maria Luisa Matey-Hernandez,Louise Keehn,Robert P Mohney,Claire J Steves,Tim D Spector,Chang-Fu Kuo,Phil Chowienczyk,Ana M Valdes

First Authors:
Cristina Menni

Correspondence:
Ana M Valdes

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