抗生素扰动菌群对过敏和哮喘的影响(综述)

Trends in Immunology

4/11/18Review

13.287

影响因子

原标题:抗菌素作为菌群失调的煽动者:对哮喘和过敏的影响

① 抗生素扰动共生菌群,可增加二次感染、耐药菌传播、过敏和哮喘的风险;② 共生菌及其产物,可通过直接(生态位竞争)和间接(刺激宿主免疫系统)的定殖抵抗,抑制致病菌;③ 也能诱导免疫系统产生抗炎症反应,抑制自身免疫和过敏疾病;④ 大部分流行病学研究表明,生命早期使用抗生素和之后的特应性疾病存在关联;⑤ 动物实验证据也证明大部分抗生素对过敏性疾病有不良影响,特定细菌可加剧或缓解过敏和哮喘;⑥ 应开发更精准的抗生素和替代疗法。

抗生素 菌群失调 过敏 哮喘 特应性 定殖抵抗

图片

Title:
Antibiotics as Instigators of Microbial Dysbiosis: Implications for Asthma and Allergy

DOI:
10.1016/j.it.2018.02.008

Abstract & Authors展开

Abstract:
The human body and its resident microbiota form a complex ecosystem, shaped by both inherited and environmental factors. The use of antibiotics represents an extreme example of environmental pressure and can broadly disrupt the microbial landscape. The benefits that antibiotics have brought to modern medicine are unquestionable; however, their overuse comes with consequences, including the potential for secondary infections by opportunistic pathogens and the spread of antibiotic resistance. Here, we discuss the implications of microbial dysbiosis driven by antibiotics, with a focus on potential links with allergy and asthma. We review epidemiological data on humans, as well as mechanistic studies performed in animal models, and highlight gaps in current knowledge, which if addressed, could drive the design of novel therapeutic strategies and improved clinical care.

All Authors:
Tomasz P Wypych, Benjamin J Marsland

First Authors:
Tomasz P Wypych

Correspondence:
Tomasz P Wypych, Benjamin J Marsland

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