JAMA:菌群如何影响动脉粥样硬化风险?

JAMA

5/14/18Opinion

44.405

影响因子

原标题:微生物组与动脉粥样硬化风险

① 菌群是人体的第二个基因组,也是额外的内分泌器官,肠道菌群可影响动脉粥样硬化;② 菌群可影响肥胖、2型糖尿病、脂代谢和血压等动脉粥样硬化风险因素,尤其是菌群失调引起的肠漏和系统性炎症可触发胰岛素抵抗;③ 菌群还可直接影响动脉粥样硬化斑块的形成,包括引起慢性炎症、影响内皮细胞功能和TMAO水平;④ 有望开发菌群相关疗法,但现有研究中大部分结论基于动物模型、TMAO的作用仍存争议、对病毒组认识不足,仍应保持批判性态度。

动脉粥样硬化

图片

Title:
The Microbiome and Risk for Atherosclerosis

DOI:
10.1001/jama.2018.5240

Abstract & Authors展开

Abstract:
Hot new areas of biomedicine sometimes generate cool skepticism. Little more than a decade ago, investigators proposed that the gut microbiome might be contributing to obesity. Since then, the microbiome has been linked to numerous major diseases, including atherosclerosis, although some have been skeptical about this association.

All Authors:
Anthony L Komaroff

First Authors:
Anthony L Komaroff

Correspondence:
Anthony L Komaroff

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