江南大学:甘露寡糖促进二甲双胍的降血糖作用

Journal of Agricultural and Food Chemistry

4/27/18Article

3.154

影响因子

原标题:益生元甘露寡糖增强了二甲双胍与调节肠道菌群相关的降血糖效应

① 二甲双胍治疗2型糖尿病可能引起肠道不适;② 研究二甲双胍与益生元甘露寡糖(MOS)结合使用对肠道的功效;③ 二甲双胍与MOS结合使用在缓解胰岛素抗性、改善葡萄糖耐受性、胰岛及肝组织学修复方面具有协同作用;④ 另外二甲双胍与MOS结合使用,降低了理研菌科和梭菌目的丰度,同时增加了OTU05945(属于S24-7),Akk菌和长双歧杆菌的丰度;⑤ 结果提示MOS可增强二甲双胍的降血糖作用,机制与调节肠道菌群相关。

益生元 2型糖尿病 二甲双胍 甘露寡糖

图片

Title:
Prebiotic mannan-oligosaccharides augment the hypoglycemic effects of metformin in correlation with modulating gut microbiota

DOI:
10.1021/acs.jafc.8b00829

Abstract & Authors展开

Abstract:
Type 2 diabetes (T2D) induced by obesity and high-fat diet is significantly associated with gut microbiota dysbacteriosis. Due to the first line clinical medicine of metformin has several intestinal drawbacks, combination usage of metformin with a prebiotic of konjac mannan-oligosaccharides (MOS) was conceived and implemented aiming to investigate whether there was some intestinal synergetic effects and how MOS would function. Composite treatment of metformin and MOS demonstrated synergistic effects on ameliorating insulin resistance and glucose tolerance, and repairing islet and hepatic histology. In addition, MF+MOS altered the gut community composition and structure by decreasing the relative abundances of family Rikenellaceae and order Clostridiales while increasing an unnamed OTU05945 of family S24-7, Akkermansia muciniphila, and Bifidobacterium pseudolongum. The present study suggested that usage of MOS could augment the hypoglycemic effects of metformin in association with gut microbiota modulation, which could provide references for further medication.

All Authors:
Jialin Zheng,Heng Li,Xiaojuan Zhang,Min Jiang,Chunqin Luo,Zhenming Lu,Zheng-Hong Xu,Jin-Song Shi

First Authors:
Jialin Zheng

Correspondence:
Heng Li, Jin-Song Shi

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